Synthesis, Spectroscopic Characterization, Biological Activity, and Molecular Docking Studies of a Novel Cu(II) Bipyridine-Based Complex
DOI:
https://doi.org/10.64354/e5z8b093Keywords:
5,5'-dimethyl-2,2'-bipyridine; Piperidine-2-carboxamide; Bipyridyl derivatives; Copper (II) complex; Ligand.Abstract
A newly synthesized multidentate ligand based on a 2,2'-bipyridine derivative and containing a diamide functionality was prepared and the resulting complex with copper (II) was studied for the ligand/copper-binding characteristics (despite the nature of being different). Preparation of the ligand was achieved through oxidation of the (describe a possible future event) or the 5,5'-dimethyl-2,2'-bipyridine compound to produce the acid derivatives, which were converted to acid chloride derivatives using thionyl chloride. In subsequent steps the acid chloride was reacted with Pipecolic Acid (Piperidine-2-carboxamide) to yield the diamide functionalized ligand (match each item with an appropriate subsequent item). The identities of the diamide-functionalized ligand and ligand/copper complex were confirmed by elemental analysis, HNMR., 13C NMR, FTIR, and mass spectrometry. The interactions between the ligand/copper complex and the target proteins (Staphylococcus aureus, a Gram positive bacteria, Gram negative Escherichia coli b) were documented through a molecular docking study. The binding energy, type of bond and length of the prepared molecules and amino acids in the complex have been studied. Each type of bond explained in the previous two paragraphs will be compared to the binding energy of the complex. The two types of bacteria used for testing will be the Gram-positive and Gram-negative. (e.g., Staphylococcus aureus.) The (useful in regulating the body) activity of the complex in stopping the action of both types of bacteria is being studied. Researchers evaluated the efficacy of an unprepared clinical [designated as 'complex N'] against bacteria in addition to evaluating the individual efficacy of [unprepared clinical] and [prepared clinical]. Additionally, they compared these results for all agents and found that 'complex N' had a substantially much higher positively-correlated effect than all other unprepared clinical agents.
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